What supplements does Bryan Johnson take?

Bryan Johnson takes over 100 supplements daily as part of his Blueprint protocol. The core stack available to the public includes Essential Capsules (24 nutrients), Longevity Mix, Omega-3, Collagen Peptides, and Extra Virgin Olive Oil. These are third-party tested and formulated at clinically-studied doses.

What is the Blueprint protocol?

The Blueprint protocol is Bryan Johnson's comprehensive anti-aging and longevity regimen. It combines diet, exercise, sleep optimization, and science-backed supplements to reverse biological age. Johnson has spent over $4 million researching and measuring 70+ organs to develop this protocol.

Are Blueprint supplements worth it?

Blueprint supplements use premium, bioavailable ingredients at clinically-effective doses, unlike drugstore vitamins that often use "pixie dusting" (ineffective amounts). Every batch is third-party tested for purity and heavy metals. While more expensive than generic supplements, they provide superior quality and transparency.

How long until I see results from Blueprint supplements?

Many users report improved energy and sleep within 2-4 weeks of starting Blueprint supplements. However, the deeper cellular benefits that affect biological age build over months. Bryan Johnson recommends committing to at least 90 days for optimal results.

Can supplements actually reverse biological age?

Research shows that certain supplements combined with lifestyle changes can reduce biological age. Studies have demonstrated 4-5 year reductions in biological age over 8-16 weeks with proper supplementation including vitamin D, NMN, and omega-3s, alongside diet and exercise optimization.

Science-Backed Anti-Aging Guide

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What Are Longevity Supplements?

Longevity supplements are compounds that target the biological pathways of aging. Unlike general health supplements, these specifically aim to slow or reverse the aging process at the cellular level—supporting NAD+ levels, reducing inflammation, protecting telomeres, and optimizing mitochondrial function.

The field of anti-aging supplements has exploded in recent years, with research from institutions like Harvard, MIT, and Stanford validating compounds that can measurably impact biological age.

Bryan Johnson, who has invested over $4 million in longevity research on himself, has distilled the most effective supplements into the Blueprint stack—making these benefits accessible to everyone.

Key Longevity Supplements Backed by Science

These are the most researched anti-aging supplements with strong evidence for longevity benefits.

NMN (Nicotinamide Mononucleotide)

Precursor to NAD+, essential for cellular energy and DNA repair

Research Says:

Studies show NMN can improve insulin sensitivity, energy metabolism, and physical endurance

Found In:

Blueprint Longevity Mix

Omega-3 Fatty Acids (EPA/DHA)

Critical for brain health, heart function, and reducing inflammation

Research Says:

Higher omega-3 levels associated with 5+ years longer telomere length

Found In:

Blueprint Omega-3

Curcumin

Powerful anti-inflammatory and antioxidant properties

Research Says:

May help reduce age-related cognitive decline and joint inflammation

Found In:

Blueprint Essential Capsules

Collagen Peptides

Supports skin elasticity, joint health, and connective tissue

Research Says:

Clinical studies show improved skin hydration and reduced wrinkle depth

Found In:

Blueprint Collagen Peptides

Vitamin D3 + K2

Essential for bone health, immune function, and calcium metabolism

Research Says:

Optimal vitamin D levels associated with reduced all-cause mortality

Found In:

Blueprint Longevity Mix

CoQ10 (Ubiquinol)

Mitochondrial support and cellular energy production

Research Says:

Levels decline with age; supplementation supports heart and brain function

Found In:

Blueprint Essential Capsules

Blueprint vs. Drugstore Supplements

Not all longevity supplements are created equal. Here's how Blueprint supplements compare to typical drugstore options.

Factor	Blueprint	Drugstore
Clinical Dosages	✓	✗
Third-Party Tested	✓	Sometimes
Heavy Metal Tested	✓	Rarely
COAs Published	✓	✗
Synergistic Formulation	✓	✗
Research-Backed	✓	Variable

How To Choose Longevity Supplements

1. Check for Clinical Doses

Many supplements contain ineffective "pixie dust" amounts. Look for products that list specific doses matching clinical research.

2. Verify Third-Party Testing

Independent lab verification ensures what's on the label is actually in the bottle. Look for published Certificates of Analysis.

3. Consider Bioavailability

Some forms of nutrients are better absorbed than others. Quality supplements use the most bioavailable forms.

4. Look for Synergy

The best longevity stacks are designed so ingredients work together, enhancing overall effectiveness.

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